Other Lecture or Seminar

Comparing the Time to Response in Antidepressant Clinical Trials

Dr. Roy Tamura
Eli Lilly & Company

Start Date and Time: Mon, 5 Nov 2001, 4:30 PM

End Date and Time: Mon, 5 Nov 2001, 6:00 PM

Venue: LAEB B222

Abstract:

Current antidepressants have a delayed onset of action and there is considerable interest in developing new products which exhibit a shorter time to response. In this talk, I will outline the medical background of depression, and psychiatric clinical trials. I will introduce the cure model which has been used in oncology clinical trials; this model has some attractive features for the problem of differentiating speed of onset. I will describe some of our own proposed methods involving the cure model which include a Cramer-von Mises type test statistic and a bootstrap procedure, and I will also describe some very recent work done by others which combine logistic regression, and proportional hazards model into the cure model.