Title: "Long-Read Sequencing with the GS FLX System: Data Processing and Analysis"
Speaker: My-Hanh Thi Nguyen, Ph.D.; Regional Applications Consultant (Bioinformatics), Roche Applied Science
Place: Physics (PHYS) 112; March 2, 2010, Tuesday, 4:30pm


In this talk, we will provide an overview of the Roche Genome Sequencer FLX System featuring 454 pyrosequencing, a powerful technology for genetics-based research and other applications. Delving more deeply into data processing, pipeline, and filtering, we will also focus on the GS FLX Linux-based data analysis software packages. These include the GS De Novo Assembler with the newly released cDNA de novo assembly algorithms and annotation tool, as well as GS Reference Mapper and Amplicon Variant Analyzer software. In addition, we will highlight upcoming developments and exciting new applications using Roche next-generation sequencing technology.

454, 454 SEQUENCING, and GS FLX are trademarks of Roche. Other brands or product names are trademarks of their respective holders. For life science research only. Not for use in diagnostic procedures.

Associated Reading:

1. Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in Arabidopsis thaliana; E. A. Vidal et al, PNAS, 2009.

2. MicroRNA and tasiRNA diversity in mature pollen of Arabidopsis Thaliana; R. Grant-Downton et al, BMC Genomics, 2009.

3. Complete Khoisan and Bantu genomes from southern Africa; S. C. Schuster et al, Nature, 2010.

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