I
currently focus my research on developing a new regularized variable
selection for high-dimensional data, and applying it to whole-genome
association study, whole-genome animal selection, eQTL mapping, and
gene-environment interaction.
Statistical Methodologies
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Bayesian Analysis, Empirical Likelihood
Approach, Graphical Models, Multivariate Extreme Values, Multivariate Statistics,
Shrinkage Estimators
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D. Zhang, Y. Lin and M. Zhang (2008). Penalized
orthogonal-components regression for large p small n data.
arXiv:0811.4167v1[stat.ME]. |
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M. Zhang, D. Zhang and M.T. Wells (2008). Generalized
shrinkage estimators adaptive to sparsity and asymmetry of high
dimensional parameter spaces.
Technical Report 08-01, Department of Statistics, Purdue
University. |
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D. Zhang, M. T. Wells and L. Peng (2008).
Nonparametric estimation of the dependence function for a
multivariate extreme
value distribution. Journal of Multivariate Analysis,
99: 577-588. |
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N.-H. Chan, L. Peng and D. Zhang (2007). Empirical-likelihood-based confidence intervals for conditional variance in heteroscedastic regression models. Accepted by Econometric
Theory. |
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D. Zhang, M. T. Wells, B. W. Turnbull, D. Sparrow and P. A.
Cassano (2005).
Hierarchical Graphical Models: An Application to Pulmonary
Function and Cholesterol Levels in the Normative Aging Study.
Journal of American Statistics Association, 100: 719-727. |
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D. Zhang, S. He and Z. Xie (1993). Outlier Detection and
Intervention for ARIMA(p,d,0). Proceedings of First Asian
Conference on Statistical Computation. |
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Statistics in Bioinformatics
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Analysis of Gene
Expression Data, Analysis of Mass Spectrometry Data, Comparative
Proteomics/Metabolomics Study, Quantitative Trait Loci Mapping,
Whole-Genome Association Study
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N. Liu, D. Zhang, and H. Zhao (2008).
Genotyping error detection in samples of unrelated individuals
without replicate genotyping.
Accepted by Human Heredity. |
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M. Zhang, D. Zhang,
and M. T. Wells (2008).
Variable selection with
large p small n regression models: mapping QTL with epistasis.
BMC Bioinformatics, 9:251. |
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D. Zhang, X. Huang, F.E. Regnier, and M.
Zhang
(2008).
Two-dimensional correlation optimized warping algorithm
for aligning GCXGC-MS data. Analytical Chemistry, 80 (8):
2664-2671. |
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D. Zhang and M. Zhang (2007).
Bayesian profiling of
molecular signatures to predict event times. Theoretical
Biology & Medical Modelling, 4:3, doi:10.1186/1742-4682-4-3. |
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D. Zhang, M. Zhang, and M. T.
Wells (2006).
Multiplicative
Background Correction for Spotted Microarrays to Improve
Reproducibility. Genetical Research, 87: 195-206. |
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M. Zhang, K. L. Montooth, M.
T. Wells, A. G. Clark and D.
Zhang (2005).
Mapping Multiple Quantitative Trait Loci by Bayesian
Classification. Genetics, 169: 2305-2318. |
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D. Zhang, M. T. Wells, C. D.
Smart, and W. E. Fry (2005).
Bayesian Normalization and Inference for Differential Gene
Expression Data. Journal of Computational Biology,
12:
391-406. |
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Complex Traits Consortium (2004).
The Collaborative Cross: A Community Resource for the Genetic
Analysis of Complex Traits. Nature Genetics, 36:
1133-1137. |
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Applied Statistics
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Analysis of Biomedical Data
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E.M. Chan, A. Wilson-Weekes, A. Suvannasankha, L.D. Cripe, A.D.
Hartman, G. Friedman, P. Worland, B. Bennett, M. Zhang, D.
Zhang, M.J. Klemsz, L.M. Boxer, H. Nakshatri and H.S. Boswell
(2007). Multidrug resistance effected by Bcl-2 in AML is
regulated
downstream of Flt3 through a JNK pathway involving c-Jun/AFT2: a
novel JNK inhibitor induces apoptosis in leukemic blasts.
Submitted. |
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T.R. Mhyre, R. Loy, P.N. Tariot, L.A.
Profenno, K.A. Maguire-Zeiss, D. Zhang, P.D. Coleman and H.J.
Federoff (2007).
Proteomic analysis of peripheral leukocytes in Alzheimer's
disease patients treated with divalproex sodium.
Neurobiology of Aging,
doi:10.1016/\\j.neurobiolaging.2007.04.004. |
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S. W. Perry, J. P. Norman, A. Litzburg, D.
Zhang, S. Dewhurst
and H. A. Gelbard (2005).
HIV-1
Transactivator of Transcription Protein Induces Mitochondrial
Hyperpolarization and Synaptic Stress Leading to Apoptosis.
Journal of Immunology, 174: 4333-4344. |
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M. Zhang, X. Wang, D. Zhang, G. Xu, H.
Dong, Y. Yu and J. Han
(2004).
Orphanin FQ Antagonizes the Inhibition of Ca2+ Currents Induced
by Mu-opioid Receptors. Journal of Molecular Neuroscience,
25: 21-27. |
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Statistical Packages
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All are developed in MATLAB. The
MATLAB
codes will be disclosed once the relevant papers are published/accepted (under
construction). All copyrights are retained by
Dabao Zhang and
Min Zhang unless
stated otherwise. They are free to use for academic purpose but it is
required to cite the relevant papers. Please
contact me for any bugs and application issues. Any
suggestion/comment is welcome!
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2DCOW: Implement the two-dimensional correlation optimized
warping algorithm proposed in Zhang, Huang, Regnier and
Zhang (2007). |
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MapMSDiff: Developed for comparative proteomic/metabolomic
studies using one-dimensional mass spectrometry data which is
described in a paper in preparation. We may extend it for
multi-dimensional mass spectrometry data in future. |
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MicroBayes: Implement the approach proposed in
Zhang, Wells, Smart, and Fry (2005). |
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GEBCauchy: Implement the generalized empirical Bayes
thresholding with Cauchy priors proposed in Zhang, Zhang and
Wells (2007). |
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GEBLaplace: Implement the generalized empirical Bayes
thresholding with Laplace priors which is developed in a
paper in preparation (see Zhang, Zhang and
Wells, 2007 for GEBT). |
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QTLBayes: Implement the Bayesian approach for QTL mapping
proposed in
Zhang, Montooth,
Wells, Clark and Zhang (2005), which is extended in
Zhang, Zhang, and Wells (2007) and another paper in
preparation. |
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SemMix: Implement the EM algorithm for mixed graphical models as
described in
Zhang, Wells, Turnbull, Sparrow and Cassano
(2005). |
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Talks
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