Research Profile

Min Zhang



1.     Zhang M. Book Review: “Design, Analysis, and Interpretation of Genome-Wide Association Scans. (2018). Biometrics. 74: 775-776.

2.     Pauli D, Ziegler G, Ren M, Jenks M, Hunsaker D, Zhang M, Baxter I, and Gore M. (2018). Multivariate analysis of the cotton seed ionome reveals integrated genetic signatures of abiotic stress response. G3: Genes, Genomes, Genetics. 8(4): 1147-1160.

3.     Chen C, Gowda N, Zhu J, Deng L, Gu H, Chiorean G, Zaid M, Harrison M, Zhang D,  Zhang M*, and Daniel Raftery*. (2017). Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis. Metabolomics. 13:125. DOI 10.1007/s11306-017-1265-0.

4.     Zhang M, Hua L, Zhai W, Zhao Y. (2017). Novel computational approaches and applications in cancer research. BioMed Research International. Editorial. Volume 2017, Article ID 9509280.

5.     Park J, Salmi ML, Wan Salim WWA, Rademacher A, Wickizer B, Schooley A, Benton J, Cantero A, Argote P, Ren M, Zhang M, Porterfield DM, Ricco AJ, Roux SJ, and Rickus JL. (2017). An autonomous lab on a chip for space flight calibration of gravity-induced transcellular calcium polarization in single-cell fern spores. Lab on a Chip. 17:1095-1103.

6.     Guan L, Wang Q, Wang L, Wu B, Chen Y, Liu F, Ye F, Zhang T, Li K, Yan B, Lu C, Su L, Jin G, Wang H, Tian H, Wang L, Chen Z, Wang Y, Chen J, Yuan Y, Cong W, Zheng J, Wang J, Xu X, Liu H, Xiao W, Han C, Zhang Y, Jia F, Qiao X, Genetic REsearch on schizophreniA neTwork-China and Netherland (GREAT-CN),  Zhang D, and Zhang M*, and Ma H* (co-corresponding authors, 2016). Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain. Molecular Psychiatry. 21(9): 1244-1250.

7.     Shi C, Zheng Z, Wang Q, Wang C, Zhang D, Zhang M*, Chan P*, Wang XM* (co-corresponding authors, 2016). Exploring the effects of genetic variants on clinical profiles of Parkinson’s disease assessed by the Unified Parkinson’s disease rating scale and the Hoehn-Yahr score. PLos One. 11(6): e0155758.

8.     Neumann E, Mehboob H, Ramirez J, Mirkov S, Zhang M, and Liu W. (2016). Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children.  Frontiers in Pharmacology. 7: Article 437.

9.     Reyes-Fernandez P, Replogle RA, Wang L, Zhang M, Fleet JC. (2016). Novel genetic loci control calcium absorption and femur bone mass as well as their response to low calcium intake in male BXD recombinant inbred mice. Journal of Bone and Mineral Research. 31(5): 994-1002.

10.  Fleet JC, Replogle RA, Reyes-Fernandez P, Wang L, Zhang M, Clinkenbeard EL and White KE. (2016) Gene-by-Diet Interactions Affect Serum 1,25 dihydroxyvitamin D Levels in Male BXD Recombinant Inbred Mice. Endocrinology. 157(2): 470-481.

11.  Pungpapong V, Zhang M, Zhang D. (2015). Selecting massive variables using an iterated conditional modes / medians algorithm. Electronic Journal of Statistics. 9(1): 1243-1266.

12.  Lin Y, Zhang M, Zhang D. (2015). Generalized orthogonal-components regression for high-dimensional generalized linear models. Computational Statistics and Data Analysis. 88: 119-127.

13.  Chen C, Deng L, Wei S, Gowda N, Gu H, Chiorean EG, Zaid MA, Harrison ML, Pekny JF, Loehrer PJ, Zhang D, Zhang M*, and Raftery D*. (co-corresponding authors, 2015) Exploring metabolic profile differences between colorectal polyp patients and controls using seemingly unrelated regression. Journal of Proteome Research. 14(6): 2492-2499.

14.  Eisenberg T, Eisenberg M, Wells MT, Zhang M. (2015). Addressing the zero problem: regression models for outcomes with a large proportion of zeros, with an application to trial outcomes. Journal of Empirical Legal Studies. 12(1): 161-186.

15.  Wang L, Athinarayanan S, Jiang G, Chalasani N, Zhang M, Liu W. (2015). Fatty acid desaturase 1 (FADS1) gene polymorphisms control human hepatic lipid composition. Hepatology. 61: 119-128.

16.  Pinson SRM, Tarpley L, Yan W, Yeater K, Lahner B, Yakubova E, HuangX, Zhang M, Guerinot ML, Salt DE. (2015). Worldwide genetic diversity for mineral element concentrations in rice grain. Crop Science. 55: 1-18.

17.  Xue X, Shi Z, Wang W, Yu X, Feng P, Zhang M, Wang X, Xu J. (2015). Huqi San-evoked rat colonic anion secretion through increasing CFTR expression. Evidence-Based Complementary and Alternative Medicine. Article ID 301640.

18.  Zhang M, Pinson SRM, Tarpley L, Huang B, Lahner B, Yakubova E, Baxter I, Guerinot ML, Salt DE. (2014). Mapping and validation of quantitative trait loci associated with concentration of 16 elements in unmilled rice grain. Theoretical and Applied Genetics. 127(1): 137-165.

19.  Li C, Wei R, Johnes-Hall Y, Vittal R, Zhang M, and Liu W. (2014). Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: An association study. Scientific Reports. 4: 4893.

20.  Wei R, Li C, Zhang M, Jones YL, Myers JL, Noth I, Liu W. (2014). Association between MUC5 B and TERT polymorphisms and different interstitial lung disease phenotypes. Translational Research. doi: 10.1016/j.trsl.2013.12.006.

21.  Athinarayanan S, Wei R, Zhang M, Bai S, Traber MG, Yates K, Cummings OW, Molleston J, Liu W and Chalasani N. (2014). Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological responses in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials. PLoS One. 9(4): e95366.

22.  Replogle RA, Li Q, Wang L, Zhang M, Fleet JC. (2014). Gene-by-diet interaction influence calcium absorption and bone density in mice. Journal of Bone and Mineral Research, 29(3): 657-665.

23.  Gamazon ER, Innocenti F, Wei R, Wang L, Zhang M, Mirkov S, Ramirez R, Huang RS, Cox NJ, Ratain MJ, Liu W. (2013). A genome-wide integrative study of microRNAs in human liver. BMC Genomics, 14: 395.

24.  Li H, Wang YJ, Hua L, Yang YT, Zhang M, Zhang D, Wang C, Xu ZQ. (2013). Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 45:7-10.

25.  Pungpapong V, Muir WM, Li X, Zhang D, and Zhang M. (2012). A fast and efficient approach for genomic selection with high density markers. G3: Genes, Genomes, Genetics, 2(10): 1179-84.

26.  Isailovic D, Plasencia MD, Gaye MM, Stokes ST, Kurulugama RT, Pungpapong V, Zhang M, Kyselova Z, Goldman R, Mechref Y, Novotny MV, and Clemmer DE. (2012). Delineating diseases by IMS-MS profiling of serum N-linked glycans. Journal of Proteome Research, 11: 576-585.

27.  Pungpapong V, Wang L, Lin Y, Zhang D, and Zhang M. (2011). Genome-wide association analysis of GAW17 data using an empirical Bayes variable selection. BMC Proceedings, 5 (Suppl 9): S4.

28.  Wang L, Pungpapong V, Lin Y, Zhang M, and Zhang D. (2011). Genome-wide case-control study in GAW17 using coalesced rare variants. BMC Proceedings, 5 (Suppl 9): S110.

29.  Li X, Zhu C, Lin Z, Wu Y, Zhang D, Ma J, Song W, Bai G, Muehlbauer G, Scanlon M, Zhang M, and Yu J. (2011). Chromosome size in diploid eukaryotic species centers on the average length with a conserved boundary. Molecular Biology and Evolution, 28(6): 1901-1911.

30.  Zhang M, Zhang D, and Wells MT. (2010). Generalized thresholding estimators for high-dimensional location parameters. Statistica Sinica, 20: 911-926.

31.  Zhang M. (2010). Bayesian classification method for QTL mapping. Bayesian Modeling in Bioinformatics, edited by Dey, Ghosh, and Mallick.

32.  Zhang M, and Cowen M. (2010). Statistical based analysis and modeling. Handbook of Healthcare Delivery Systems, edited by Yih.

33.  Buescher E, Achberger T, Amusan I, Giannini A, Ochsenfeld C, Rus A, Lahner B, Hoekenga O, Yakubova E, Harper JF, Guerinot ML, Zhang M, Salt DE, Baxter IR. (2010). Natural genetic variation in selected populations of Arabidopsis thaliana is associated with ionomic differences. PLoS ONE, 5(6): e11081.

34.  Sari Y, Zhang M, and Mechref, Y. (2010). Differential expression of proteins in fetal brains of alcohol-treated prenatally C57BL/6 mice: a proteomic investigation. Electrophoresis, 31(3): 483-496.

35.  Hammoud ZT, Mechref Y, Hussein A, Bekesova S, Zhang M, Kesler KA, and Novotny MV. (2010). Comparative glycomic profiling in esophageal adenocarcinoma. The Journal of Thoracic and Cardiovascular Surgery. 139 (5): 1216-1223.

36.  Zhang M, Lin Y, Wang L, Pungpapong V, Fleet JC, and Zhang D. (2009). Case-control genome-wide association studies of rheumatoid arthritis from GAW16 using POCRE-LDA. BMC Proceedings, Suppl 7: S17.

37.  Lin Y, Zhang M, Wang L, Pungpapong V, Fleet JC, and Zhang D. (2009). Simultaneous genome-wide association studies of anti-CCP in rheumatoid arthritis using penalized orthogonal-components regression. BMC Proceedings, Suppl 7: S20.

38.  Jedicka SS, Dadarlat M, Hassell T, Lin Y, Zhang M, Irazoqui P, Rickus J. (2009). Calibration of neurotransmitter release from neural cells for therapeutic implants. International Journal of Neural Systems, 19: 197-212.

39.  Zhang D, Lin Y, and Zhang M. (2009). Penalized orthogonal-components regression for large p small n data. Electronic Journal of Statistics, 3: 781-796.

40.  Zeng L, Salvendy G, and Zhang M. (2009). Factor structure of web site creativity. Computers in Human Behavior, 25: 568-577.

41.  Mechref Y, Hussein A., Bekesova S, Punpapong V, Zhang M, Dobrolecki LE, Hickey RJ, Hammoud ZT, Novotny MV. (2009). Quantitative serum glycomics of esophageal adenocarcinoma and other esophageal disease onsets. Journal of Proteome Research, 8: 2656-2666.

42.  Zhang M, Zhang D, and Wells MT. (2008). Variable selection with large p small n regression models: mapping QTL with epistasis. BMC Bioinformatics, 9:251.

43.  Zhang D, Huang X, Regnier F, and Zhang M. (2008). Two-dimensional correlation optimized warping algorithm for aligning GC´GC-MS data. Analytical Chemistry, 80(8): 2664-2671.

44.  Zhang D, and Zhang M. (2007). Bayesian profiling of molecular signatures to predict event times. Theoretical Biology and Medical Modelling, 4: 3.

45.  Zhang, M, Strawderman, R., Cowen, M., and Wells, M.T. (2006). Bayesian Inference for a two-part hierarchical model: an application to profiling providers in managed health care. Journal of the American Statistical Association, 101: 934-945.

46.  Zhang D, Zhang M, and Wells MT. (2006). Multiplicative background correction for spotted microarrays to improve reproducibility. Genetical Research, 87: 195-206.

47.  Zhang M, Montooth KL, Wells MT, Clark AG, and Zhang D. (2005). Mapping multiple quantitative trait loci by Bayesian classification. Genetics, 169: 2305-2318.

48.  Zhang M, Wang X, Zhang D, Xu G, Dong H, Yu Y, and Han J. (2005). Orphanin FQ antagonizes the inhibition of Ca2+ currents induced by m-opioid receptors. Journal of Molecular Neuroscience, 25: 21-28.

49.  Dong H, Wang L, Zhang M, and Han J. (2005). Decreased dynorphin A (1-17) in the spinal cord of spastic rats after compressive injury. Brain Research Bulletin, 67: 189-195.

50.  The Complex Trait Consortium. (2004). The collaborative cross: a community resource for the genetic analysis of complex traits. Nature Genetics, 36(11): 1133-1137.

51.  Zhang M, Sun Q, Wan Y, Yao L, Yu Y, and Han J. (1998). OFQ reverses the opioid receptor-mediated depression of calcium current in rat dorsal root ganglion neurons. NeuroReport, 9: 2095-2098.



Statistical Packages and Data

·       2DCOW: Implement the two-dimensional correlation optimized warping algorithm proposed in Zhang, Huang, Regnier and Zhang (2008).

·       GEBLaplace: Implement the generalized empirical Bayes thresholding with Laplace priors which is developed in a paper in preparation (see Zhang, Zhang and Wells, 2009 for GEBT).

·       QTLBayes: Implement the Bayesian approach for QTL mapping proposed in Zhang, Montooth, Wells, Clark and Zhang (2005), which is extended in Zhang, Zhang, and Wells (2008) and another paper in preparation.

·       GEBCauchy: Implement the generalized empirical Bayes thresholding with Cauchy priors proposed in Zhang, Zhang and Wells (2009).

·       PD data: for Chen et al., Plos ONE (2016).