Title: "Systems Biology in Medicine: Applications to Anemia, Diabetes, and Cancer"
Speaker: Nathan Price, Department of Chemical and Biomolecular Eng, Inst for Genomic Biology, Univ IL, Urbana-Champaign, IL
Place: Mechanical Engineering (ME) 161; February 5, 2008; Tuesday, 4:30pm


Systems biology, the intersection of high-performance computing with high-throughput experimental technologies to drive biological discovery, has the potential to transform the practice of medicine to a more predictive and personalized discipline. These technologies enable the reconstruction and modeling of large-scale biochemical networks in human systems that can aid in the understanding, and eventual control, of disease phenotypes. In addition, disease-perturbed biomolecular networks result in altered levels of gene and protein expression that necessarily leave molecular fingerprints that can be identified for accurate disease diagnosis to aid in the selection of appropriate therapies for the patient. Systems approaches to human disease will be illustrated in three cases: hemolytic anemia, diabetes, and cancer.

Associated reading:

Nathan D. Price, Jonathan Trent, Adel K. El-Naggar, David Cogdell, Ellen Taylor, Kelly K. Hunt, Raphael E. Pollock, Leroy Hood, Ilya Shmulevich, and Wei Zhang. 2007. Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas. Proceedings of the National Academy of Sciences. USA. 104(9):3414-3419.

Nathan D. Price, Lucas B. Edelman, Inyoul Lee, Hyuntae Yoo, Daehee Hwang, George Carlson, David J. Galas, James R. Heath, and Leroy Hood. 2008. Systems Biology and the Emergence of Systems Medicine. Prepared for Genomic and Personalized Medicine: From Principles to Practice (Ginsburg, G. and Willard, H., editors). Elsevier, in press.

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