Title: "3-D reconstruction problems for viruses"
Speaker: Dr. Peter Doerschuk , Department of Electrical and Computer Engineering, Purdue University, W. Lafayette, IN
Place: SMITH 108; March 2, 2004; Tuesday, 4:30pm


Understanding the 3-D structure of a virus particle as it progresses through its lifecycle is an important part of understanding, and potentially modifying, its behavior. Computing the 3-D structure of a virus from electron microscope images of ensembles of identical virus particles is a tomography problem with several unusual characteristics. These characteristics include low SNR, unknown projection orientations for the 2-D projections of the 3-D viral electron scattering intensity, and linear modification of the projections by a circularly-symmetric frequency response with zeros which is basically known. A statistical approach to this 3-D signal reconstruction problem will be described that includes both planning experiments and analyzing the results of experiments. A variety of numerical examples will be presented.

See http://www.stat.purdue.edu/~doerge/BIOINFORM.D/SPRING04/sem.html for a full scheule of BIOINFORMATICS SEMINARS.