Title:``Gene Mapping on a Pedigree of Inbred Lines''
Speaker: Amy Anderson, Department of Statistics, University of Washington
Place: LILLY G126; Tuesday, 4:30pm


For generations, researchers have been crossing inbred lines to create new inbred lines. Currently, there is interest in exploiting the extensive relationships between these lines to aid in gene mapping. We will present a method for adapting pedigree-based methods (such as are used in many gene mapping studies in humans) to data on inbred lines. In this method, the mating of two lines to produce a new line will be considered as analogous to a mating in which two parents produce a child. This will be done in a way that provides flexibility with regard to the number of generations of inbreeding and the choice of model for the crossover process.