Title: "From the Lab to the Clinic: Capitalizing on Multiple Omics Datatypes to Identify Causal Variants and Biologic Pathways for Asthma"
Speaker: Jessica Lasky Su; Department of Medicine, Brigham and Women's Hospital, Boston, MA.

Place: LILLY Hall G126
Date: November 10, 2015; Tuesday
Time: 4:30pm

Asthma is a disease with high public health impact, with asthma exacerbations costing more than $50 billion dollars spent annually. Asthma is a heritable disease and although a number of molecular determinants have been identified, much of the pathophysiology remains elusive. Modern technologies have enabled the generation of multiple forms of omics data, including genomics, transcriptomics, epigenomics, and metabolomics. Using integrative statistical techniques and network biology approaches with transcriptomic and metabolomic data, we have identified key disease pathways for asthma that have been validated using multiple forms of omics data in independent cohorts. We discuss how integrative methods were used, beginning with the study design, to the generation of omics data, through the analysis, and finishing with the translation to personalized clinical care. We will conclude the talk with a discussion about how these findings may translate into clinical implications for individuals diagnosed with asthma.

Associated reading:
E.K. Silverman and J. Loscalzo. 2012. Network Medicine Approaches to the Genetics of Complex Diseases. Discovery Medicine. 14(75):143-152

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