Title: "Associating Rare-Genetic Variants with Complex Traits"
Speaker: Paul L. Auer; Division of Public Health Science, Fred Hutchinson Cancer Research Center

Place: LILY G126
Date: November 13, 2012; Tuesday

Recently there has been a great deal of interest in understanding the role of rare-genetic variation underlying common complex traits. To investigate rare-genetic variation, microarray based Genome Wide Association Studies have been replaced by large scale next-generation sequencing studies. Although these studies produce vastly more fine-scale information on genetic variation, they do so at significant financial, computational, and statistical costs. In this talk I will discuss some of the obstacles we face when analyzing rare-genetic data, some solutions, and a few success stories.

Associated Reading:
Jennifer Asimit and Eleftheria Zeggini. 2012. Rare Variant Association Analysis Methods for Complex Traits. www.annualreviews.org

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