Title: "Statistical Issues in Mass Spectrometry-Based Proteomics"
Speaker: Mr. Tim Clough, Department of Statistics, Purdue University
Place: LILLY G126; September 7, 2010, Tuesday, 4:30pm


Proteomics, or the large-scale study of proteins, is an emerging field with much promise for learning about the molecular and cellular biology of an organism. Recent advances in mass spectrometry-based technologies have made it possible to accurately identify and quantify thousands of proteins in a single biological sample.

In this talk, I will introduce basic concepts in the area of mass spectrometry-based proteomics, discuss quantitative challenges in the area, and highlight similarities and differences in the field as compared to genomics.

I will discuss my recent research visit at the Institute for Molecular Systems Biology at ETH Zurich, and will use an experiment performed at the IMSB as a case study to illustrate statistical issues in the analysis of data from proteomic experiments.

Associated Reading:
T. Clough, M. Key, I. Ott, S. Ragg, G. Schadow, and O. Vitek. "Protein quantification in label-free LC-MS experiments". Journal of Proteome Research, 8, 5275-5284, 2009. http://pubs.acs.org/doi/abs/10.1021/pr900610q

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