Title: "An application of Functional Genomics: ELP Analysis for dissecting Regulatory Networks of Plant Disease Resistance"
Speaker: Kyunga Kim, Department of Statistics, Purdue University
Place: KRAN G016; Tuesday, October 1, 2002 4:30pm

The genetic basis of inherited traits has been of interest and studied with different approaches in many areas of science. For example, quantitative trait locus (QTL) analysis and mutant analysis in genetics, and genome sequencing and gene expression analysis in genomics. Each of these technologies has been used for investigation of regulatory networks controlling complex traits, such as disease resistance, as well as for its own purposes. However, each approach has its limitations, and provides only partial information. In this work, we define a new concept called expression level polymorphism (ELP) and introduce a functional genomics approach that applies QTL analysis to quantitative differences in the expression of genes and allows a more comprehensive dissection of complex traits and their genomic architecture. We address statistical issues that should be considered within ELP framework.