Statistical Applications in Pharmaceutical Research and Development Department of Statistics Purdue University Monday, November 5, 2001 4:30 PM in LAEB B222 Dr. Roy Tamura Eli Lilly & Company will speak on Comparing the Time to Response in Antidepressant Clinical Trials Abstract Current antidepressants have a delayed onset of action and there is considerable interest in developing new products which exhibit a shorter time to response. In this talk, I will outline the medical background of depression, and psychiatric clinical trials. I will introduce the cure model which has been used in oncology clinical trials; this model has some attractive features for the problem of differentiating speed of onset. I will describe some of our own proposed methods involving the cure model which include a Cramer-von Mises type test statistic and a bootstrap procedure, and I will also describe some very recent work done by others which combine logistic regression, and proportional hazards model into the cure model.

Home | General Info | People | Academic Programs and Courses Seminars and Events | Research | Consulting | Career Resources Related Programs and Links | Site Index | Site Search

©1999 Department of Statistics Last Update: Aug 16, 2001 Please send comments and suggestions to the Webmaster.